NIR Imaging of tablet surface by using IR Microscope

Near IR light is widely used for non-destructive analysis as an evaluation method in food and pharmaceutical industry due to it’s characteristics such as transmitting the glass container and weaker peak absorbance than Mid-IR light. Recently, this NIR analysis technique is introduced to the Process Analytical Technology which has been proposed by FDA, and it is used for evaluation of uniformity of mixed samples inside of vials, evaluation of water content by in-line measurement, and evaluation of contents in tablet by using of NIR microscope.

There are are various analysis methods using NIR spectroscopy such as dispersive type, filter type and AOTF type, while FTIR is considered to be better method due to several advantages such as wave number expandability, high through put and high accuracy of wavenumber. Jasco IR microscope system IRT-5000/7000 has a unique feature as option which is detachable detector unit, which makes it possible to extend the measurement range up to NIR in one single FT/IR system.

This time, Jasco analyzed the distribution of components on tablet surface by NIR imaging system which consists of FT/IR-6100 and IRT-7000 with NIR expansion.