Ultra high-speed analysis of cold and sinus medicines by UHPLC with photodiode array detection

Acetaminophen (paracetamol), anhydrous caffeine, hesperidin, ethenzamide, tipepidine hibenzate or apronalide etc. are known as active ingredients of cold or cinus medicines. Acetaminophen has antipyretic and analgesic effects. Anhydrous caffeine increases an analgesic effect. Hesperidin improves blood circulation and has an antiallergic effect. Ethenzamide has antipyretic, analgesic and antiphlogistic effects. Tipepidine hibenzate has antitussive and expectorant effects. Apronalide has analgesic and hypnotic effects.

In this report, active ingredients contained in cold and sinus medicines are analyzed by UHPLC with PDA detection, which enables ultra high-speed data acquisition at the rate of 100 spectra/sec.