Automated Solid Phase Extraction of tricyclic antidepressant drugs from serum

With the widespread clinical use of antidepressant drugs comes the need to accurately measure therapeutic levels to determine proper dosage, as well as check for toxic levels and patient compliance. More and more laboratories are shifting their therapeutic drug monitoring from liquid extraction to solid phase extraction. A large clinical laboratory has automated the process of extracting these drugs from serum using the RapidTrace SPE workstation.