Extraction of a range of acidic, basic and neutral drugs from plasma using ISOLUTE PLD+ plates prior to LC-MS/MS analysis
Resource type:
Application note
Format:
pdf
Date of creation:
20 September 2017
Library code:
11279
ISOLUTE PLD+ protein and phospholipid removal plates provide very effective but extremely simple sample cleanup for LC-MS/MS analysis. Requiring next to no method development, ISOLUTE PLD+ can be integrated quickly and easily into routine workflow, increasing productivity and reducing instrument downtime. ISOLUTE PLD+ plates remove >99% of plasma proteins and phospholipids, the main causes of ion suppression, leading to cleaner extracts and increased sensitivity (signal to noise) for a broad range of analytes.
This application note describes the use of the ISOLUTE PLD+ protein and phospholipid removal plate for clean-up of a range of acidic, basic and neutral drugs from plasma.
