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Extraction of MI (methylisothiazolinone) from sun lotion using ISOLUTE SLE+ prior to GC/MS analysis

Resource type: 
Application note
Author(s): 
Biotage
Format: 
pdf
Date of creation: 
21 October 2017
Library code: 
11304

Methylisothiazolinone (MI) is an antimicrobial preservative that can potentially be used in a variety of personal care products. However a percentage of the population is at risk from contact dermatitis when exposed to this compound at sufficient concentrations.

ISOLUTE SLE+ (Supported Liquid Extraction) columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation and significantly reduced sample preparation.

This application note describes the extraction of methylisothiazolinone from sun lotion, prior to GC/MS analysis. An effective and efficient ISOLUTE SLE+ protocol optimized for the 1 mL sample capacity column format is described.

PDF icon Download Application note, Extraction of MI (methylisothiazolinone) from sun lotion using ISOLUTE SLE+ prior to GC-MS analysis.pdf (629.83 KB)