Dynamic Extractions HPCCC instruments

Maximising both purity and recovery

Preparative Scale Purification Systems

The HPCCC range of liquid chromatography systems offered by Dynamic Extractions is suitable for applications from analytical scale to large scale preparative chromatography. It is this range of application scale that allows chemists and chromatographers to develop separations at the milligram scale and then easily scale to whatever amount their purified compound needs.

The Spectrum and Midi HPCCC instruments come fitted with two columns in their standard configuration. This allows users to quickly screen samples and develop methods with milligrams of compound before scaling up to inject grams of material.

Applications

Dynamic Extractions offers solutions to the challenges facing preparative chromatography by providing liquid-liquid instruments of high sample mass capacity, tuneable selectivity, and ease of scale-up. The HPCCC instrument range covers milligram to kilo-scale and therefore can be used in all process industries. The technology has been applied successfully in the following industries: pharmaceutical (drug discovery and development, contract research, traditional chinese medicines, biopharma), environmental (sample analysis), agriculture (soil analysis, trace metals, agricultural fertiliser), forensics and drug testing (toxicology), specialty chemicals, flavours and Fragrances and petrochemicals analysis.

Demonstrating the HPCCC advantage

Dynamic Extractions has fully functional applications laboratories at both their UK headquarters and in the USA.  At both of these facilities they are pleased to receive customer samples to perform feasibility studies, instrument demonstrations and outsourced contract separations.

Typical separation work performed:

• Purifications of milligram, gram and kilogram quantities of reference compounds, intermediates, drug candidates, analytical standards, metabolites, API’s
• HPCCC method development using normal and reverse phase, elution-extrusion and pH zone refi ning conditions
• Isolation of minor components of interest from complex mixtures

Interested customers should contact Norlab at norlab@norlab.fi.