Evaluation of a novel 96-well filter plate for the effective removal of serum proteins and phospholipids prior to LC-MS/MS analysis
Resource type:
Poster
Format:
pdf
Date of creation:
24 September 2017
Library code:
11282
When analyzing serum or plasma, the very nature of the matrix can cause problems with the analytical methodology. Endogenous components such as salts, proteins and phospholipids are all present and can have a marked effect on instrument response in terms of ion suppression or enhancement effects. This variation in signal can lead to quantitation issues and method reliability problems. In recent years a number of filter plates have been developed to address these specific interferences.
This poster evaluates the performance of a novel 96-well filter plate for the simultaneous removal of proteins and phospholipids prior to LC-MS/MS analysis.
