Assessment of solvent polarity upon drugs of abuse in oral fluids using supported liquid extraction prior to LC/MS analysis

The need for non-invasive drug screening that that precludes sample adulteration has become more and more attractive. As a result, detection using oral fluid devices for drugs of abuse (DOA) has come to the vanguard of the scientific community. The use of supported liquid extraction (ISOLUTE SLE+) prior to LC/MS or GC/MS can improve sample cleanliness without forfeiting sample detection within a diverse panel of DOA’s.

In this poster, Biotage demonstrates the effects of altering elution solvent polarity and pH for sample pretreatment upon the simultaneous recovery of 34 compounds comprised of opioids, benzodiazepines and stimulants to directly measure the effects of the oral fluid buffer, OraSure, upon extraction and signal intensity at presumed LOQ’s