Evaluation of drugs of abuse extraction from oral fluid using supported liquid extraction (SLE) prior to UPLC-MS/MS analysis

The supported liquid extraction (SLE) process is analogous to traditional liquid-liquid extraction (LLE) and utilizes the same water immiscible solvent systems for analyte extraction. Instead of shaking the two immiscible phases together, in SLE, the aqueous sample is immobilised on an inert support and the organic phase flows through the support, eliminating problems such as emulsion formation and low analyte recoveries.

This poster demonstrates the suitability of ISOLUTE SLE+ for the rapid and reliable extraction of multiple drugs of abuse and metabolites from oral fluid.