Analysis of two API products using UV spectrophotometry with multi-component analysis and a fiber optic dissolution analyzer by Distek

The white paper explains the theory behind the MCA algorithm methodology. Then, used in tandem with in-situ fiber optics, the accuracy of the technique is demonstrated by recovering the concentration of two APIs (active pharmaceutical ingredients) in known mixed solutions. Finally, an example is given of accurately monitoring and quantifying the dissolution profile of an actual commercial product containing two APIs, demonstrating the elimination of the need to draw samples or to perform HPLC analysis for many of these type of products.