Automated extraction of synthetic cannabinoids (SPICE) from urine using ISOLUTE SLE+ prior to LC-MS/MS
Resource type:
Application note
Format:
pdf
Date of creation:
23 October 2017
Library code:
11328
ISOLUTE SLE+ Supported Liquid Extraction plates and columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation and significantly reduced sample preparation time.
This application note describes the extraction of a range of SPICE drugs and metabolites in urine which are typically screened in forensic toxicology panels using ISOLUTE SLE+ in a 96-well plate format. Both manual (Biotage Pressure+ 96) and automated (TECAN Freedom EVO 100) processing conditions are described.
