Quantification calculations on accroma sample preparation systems

Per definition, concentration is the abundance of a constituent divided by the total volume of a mixture (e.g. mg/ml). This unit originates from the traditional way of preparing samples using volumetric flasks. Volumetric flasks are calibrated at 20°C and are filled to the mark to obtain the total volume. However, if sample matrix components (e.g. excipients) are not or partly soluble, volumetric errors appear. Furthermore, volumes depend on temperature. 

accroma sample preparation systems use a different concept as volumes are determined gravimetrically. In the accroLab software, measured masses of solvents are converted into volume by using the solvents density (ρsolvent). The general unit is the mass of a component divided by the volume of the solvent, called mass per solvent (w).